TRPV4 Mediates Acute Bladder Responses to Bacterial Lipopolysaccharides
نویسندگان
چکیده
منابع مشابه
Genetic Control of Responses to Bacterial Lipopolysaccharides in Mice
In vivo immune responses and in vitro mitogenic responses to bacterial lipopolysaccharides (LPS) have been compared in strains of C3H mice. C3H/HeJ spleen cultures did not support mitogenic responses to LPS and in vivo these mice produce low IgM responses to LPS. On the basis of these two responses, C3H/HeJ mice have been termed low LPS responders. All other strains of C3H mice tested (C3HeB/Fe...
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The immune response to microbial pathogens is initiated by recognition of specific pathogen components by host cells both at the cell surface and in the cytosol. While the response triggered by pathogen products at the surface of immune cells is well characterized, that initiated in the cytosol is poorly understood. Nod1 is a member of a growing family of intracellular proteins with structural ...
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abstract the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell wal...
متن کاملTRPV4 as a target for bladder overactivity
Several papers published in the last 2-3 years suggest that transient receptor potential vanilloid 4 (TRPV4) channels are candidates as mechanosensors in the urinary bladder (including human) and indicate that modulation (inhibition) of these channels could represent a novel therapy for overactive bladder and storage dysfunction. The effects of only agonists on the bladder have been described u...
متن کاملINFLAMMOTRY URINARY BLADDER CONDITIONS Acute bacterial cystitis
Acute bacterial cystitis This disease is present when more than 100,000 bacteria are present in 1mL of fresh urine. Patients with acute cystitis may present with disease of varying degrees of severity; In women, associated haemorrhage is common. IVU results are typically normal. However, in severe cases, generalized bullous mucosal edema may cause the bladder wall to have a cobblestone appearan...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2020
ISSN: 1664-3224
DOI: 10.3389/fimmu.2020.00799